Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-08-28
1998-04-14
Walsh, Stephen
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 4353201, 435325, 435348, 4352523, 536 2431, C12N 1516, C12N 1563, C12P 2100
Patent
active
057393079
ABSTRACT:
A novel growth factor, neurturin, is disclosed. The human and mouse amino acid sequences have been identified. Human and mouse neurturin genomic DNA sequences have been cloned and sequences and the respective cDNA sequences identified. The subcloning into vectors and the preparation of cells stably transformed with the vectors is also disclosed. In addition, methods for treating degenerative conditions using neurturin, methods for detecting gene alterations and methods for detecting and monitoring patient levels of neurturin are provided. Methods for identifying additional members of the neurturin-GDNF family of growth factors are also provided.
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Johnson, Jr. Eugene M.
Kotzbauer Paul T.
Lampe Patricia A.
Milbrandt Jeffrey D.
Pak Michael D.
Walsh Stephen
Washington University
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