Interleukin-1 antagonist

Details Interleukin-1 antagonist Interleukin-1 antagonist

1995-06-07

1998-04-14

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 691, 435 701, 435 912, 4351723, 536 235, C07K 1447, C12N 1511

Patent

active

057392820

ABSTRACT:
It is described a new interleukin-1 antagonist active both against IL-1.alpha. and IL-1.beta., a new DNA sequence encoding the Il-1 antagonist and the method for obtaining a IL-1 antagonist by the recombinant DNA technique; it is also described the prophylactic, therapeutic and diagnostic use of such new IL-1 antagonist in pathologies deriving from the IL-1 production.

REFERENCES:
patent: 5455330 (1995-10-01), Haskill et al.
C. Butcher et al. "Comparison of two promoters controlling expression of secreted or intracellular IL-1 receptor antagonist", Journal of Immunology, vol. 153, Jul. 1994, pp. 701-711.
C. A. Dinarello et al. "Blocking Il-1: Interleukin 1 receptor antagonist in vivo and in vitro", Immunology Today, vol. 12, No. 11, 1991, Cambridge GB, pp. 404-410.
N.F. Zander et al. "cDNA cloning and complete primary structure of skeletal muscle phosphorylase kinase (alpha subunit)", Proceedings of the National Academy of Sciences USA, vol. 85, May 1988, Washington US, pp. 2929-2933.
Abstract, EMBL database entry SKADECYC Accession No. X56042 (version 1); 19 Nov. 1990; Young et al.
M. Muzio et al. "Cloning and charcterization of a new isoform of the interleukin 1 receptor antagonist", Journal of Experimental Medicine, vol. 182, No. 2, 1 Aug. 1995, pp. 623-628.
Hannum, Charles H. et al., "Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor." Nature, vol. 343, pp. 336-340 (Jan. 25, 1990).
Eisenberg, Stephen P. et al., "Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist." Nature, vol. 343, pp. 341-346 (Jan. 5, 1990).
Carter, D.B. et al., "Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein." Nature, vol. 344, pp. 633-638 (Apr. 12, 1990).
Bienkowski, Michael J. et al., "Purification and characterization of interleukin-1 receptor level antagonist proteins from THP-1 cells." Journal of Biological Chemistry, vol. 265, No. 24, pp. 14505-14511 (1990).
Stockman et al. Secondary Strucutre and Topology of Interleukin-1 Receptor Antagonist Protein Determined by Heteronuclear Three-Dimensional NMR Spectorscopy, American Chemical Society vol. 31, No. 23, pp. 5237-5244, Jun. 19, 1992.
Interleukin 1 Receptor Antagonist is a Member of the Interleukin 1 Gene Family: Evolution of a Cytokine Control Mechanism, Proc. Natl. Acad. Sci., vol. 88, pp. 5232-5236, Jun. 1991.
Haskill et al, cDNA Cloning of an Intracelluar Form of the Human Interleukin 1 Receptor Antagonist Associated with Epithelium, Proc. Natl. Acad. Sci., vol. 88 pp. 3681-3685, May 1991.

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