Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1993-08-16
1995-05-16
Niebling, John
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
204299R, G01N 2726, G01N 27447
Patent
active
054157471
ABSTRACT:
A method and apparatus for controlling the velocity of electroosmotic flow (EOF) in high performance capillary electrophoresis (HPCE) are provided. The interior surface of the capillary tube is coated with a zwitterionic coating, such that the pH range within which EOF velocity may be controlled is broadened. The zwitterionic coating involves covalent, ionic or adsorptive binding of a zwitterionic species such as phosphoryl choline to the capillary wall.
REFERENCES:
patent: 5006313 (1991-04-01), Swedberg
patent: 5015350 (1991-05-01), Wiktorowicz
patent: 5143753 (1992-09-01), Novotny et al.
patent: 5151164 (1992-09-01), Blanchard et al.
patent: 5180475 (1993-01-01), Young et al.
patent: 5181999 (1993-01-01), Wiktorowicz
Mark A. Strege and Avinash L. Lagu, "Studies of Migration Time Reproducibility of Capillary Electrophoretic Protein Separations" Journal of Liquid Chromatography, 16(1) (1993) 51-68 no month available.
Hilmer Sorensen et al. "High-performance capillary electrophoresis for the determination of trypsin and chymotsypsin inhibitors and their assoication with trypsin, chymotrypsin and monoclonal antibodies" Journal of Chromatography A, vol. 652 No. 1 (Oct. 15, 1993) 189-198.
H. K. Kristensen and S. H. Hansen "Separation of polymyxins by micellar electrokinetic capillary chromatography" Journal of Chromatography 628(1993) 309-315 No month available.
Rick J. Krueger et al "Analysis of endoproteinase Arg Caction or adrenocorticotrophic hormone by capillary electrophoresis and reversed-phase high-performance liquid chromatography" Journal of Chromatography, vol. 543, No. 2 (May 10, 1991).
H. K. Kristensin and S. H. Hansen, "Micellar Electrokinetic Chromatographic Separation of Basic Polypeptides with Equal Mass to Charge Ratio Using Dynamically Modified Silica Capillaries" Journal of Liquid Chromatography 16(14) (1993) 2961-2975 No month available.
U. R. Tjaden et al "Automated isotachophoretic analyte focusing for capillary zone electrophoresis in a single capillary using hydrodynamic back-pressure programming" Journal of Chromatography, vol. 641, No. 1 (Jul. 2, 1993) 155-162.
Ranjit R. Deshmukh & Milan Bier, "Counterflow in isotachophoresis: Computer simulation and experimental studies" Electrophoresis, vol. 14, No. 3 (Mar. 1993) 205-213.
F. A. Chen et al., "Use of High Ionic Strength Buffers for the Separation of Proteins and Peptides with Capillary Electrophoresis", J. Liq. Chromatog. 15(6 & 7):1143-1161 (1992) No month available.
K. A. Cobb et al., "Electrophoretic Separations of Proteins in Capillaries with Hydrolytically Stable Surface Structures," Anal. Chem. 62:2478-2483 (Nov. 1990).
Kohr et al., "Capillary Electrophoresis with Surface Coated Capillaries", J. Microcol. Sep. 3:491-495 (1991) No month available.
Maa et al., "Impact of Wall Modifications on Protein Elution in High Performance Capillary Electrophoresis", in J. High Res. Chromatogr. 14:65-67 (Jan. 1991).
Schomburg, "Polymer Coating of Surfaces in Column Liquid Chromatography and Capillary Electrophoresis", Trends Anal. Chem. 10:163-169 (1991).
Swedberg, "Characterization of Protein Behavior in High-Performance Capillary Electrophoresis Using a Novel Capillary System", Analytical Biochem. 185:51-56 (1990) No month available.
Swedberg, "Use of Non-Ionic and Zwitterionic Surfactants to Enhance Selectivity in High Performance Capillary Electrophoresis. An Apparent Micellar Electrokinetic Capillary Chromatography Mechanism", J. Chromatogr. 503:449-452 (1990) No month available.
Hewlett--Packard Company
Niebling John
Starsiak Jr. John S.
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