Process and intermediates for preparation of 1,1-dioxopenicillan

Details Process and intermediates for preparation of 1,1-dioxopenicillan Process and intermediates for preparation of 1,1-dioxopenicillan

1982-11-01

1985-07-23

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602391, C07D49942, A61K 31425

Patent

active

045307920

ABSTRACT:
A process for the preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate which comprises reacting 1,1-dioxopenicillanoyloxymethyl 6-phenylacetamidopenicillanate or the corresponding phenoxyacetamidopenicillanate under anhydrous conditions with a halogenating agent in the presence of a reaction inert solvent to form an intermediate imino halide, addition of a primary alcohol having from one to four carbon atoms to convert the imino halide to an imino ether and subsequent hydrolysis to give the desired product.

REFERENCES:
patent: 3896110 (1975-07-01), Sellstedt
patent: 4234579 (1980-11-01), Barth
patent: 4244951 (1981-01-01), Bigham
patent: 4342772 (1982-08-01), Godtfredsen et al.
patent: 4359472 (1982-11-01), Hamanaka
patent: 4364957 (1982-12-01), Barth
patent: 4376076 (1983-03-01), Kellogg
B. Baltzer et al., Journal of Antibiotics, 33, 1183 (1980).

Affiliated with

Also associated with

Rating

Process and intermediates for preparation of 1,1-dioxopenicillan does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process and intermediates for preparation of 1,1-dioxopenicillan, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process and intermediates for preparation of 1,1-dioxopenicillan will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-633864