Pyrrolacetic amides having antiinflammatory activity

Details Pyrrolacetic amides having antiinflammatory activity Pyrrolacetic amides having antiinflammatory activity

1985-04-30

1986-03-25

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544141, 544372, 546281, C07D207323

Patent

active

045784817

ABSTRACT:
N-monosubstituted and N,N-disubstituted amides of the 1-methyl-5-p-toluoylpyrrole-2-acetic acid, which are active as antiinflammatory, analgesic, antipyretic, antisecretive and antitussive agents, are disclosed.
These amides are prepared by reacting an amine with an activated derivative of the 1-methyl-5-p-toluoylpyrrole-2-acetic acid of formula ##STR1## wherein X is an activating group suitable for promoting the formation of an amide bond.

REFERENCES:
patent: 3950012 (1976-04-01), Carson
patent: 4070368 (1978-01-01), Carson
patent: 4200645 (1980-04-01), Goudie
patent: 4379793 (1983-04-01), Badia
patent: 4396626 (1983-08-01), Ward et al.
patent: 4434175 (1984-02-01), Doherty et al.
patent: 4521538 (1985-06-01), Baglioni
Abstract of Japan Application, 0144256, Sep. 6, 1982.

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