Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1984-09-17
1986-03-25
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544 97, C07D23910, C07D26506
Patent
active
045784663
ABSTRACT:
This invention relates to the use of 6-aryluracils as antiinflammatory and antiarthritic agents and also to both novel intermediates and novel processes for the preparation of selected 6-aryluracils.
REFERENCES:
patent: 2758994 (1956-08-01), Lacey
patent: 3360523 (1967-12-01), Loux
patent: 4171429 (1979-10-01), Watanabe et al.
patent: 4507302 (1985-03-01), Fast et al.
Johnson et al., "Researches on Pyrimidines LXXIV. Synthesis of 4-Phenylcytosine," J. Am. Chem. Soc., vol. 37, pp. 378-383 (1915).
Gershon et al., "Pyrimidines. III. Some 6-Substituted Di- and Trichloropyrimidines," J. Med. Chem., vol. 6, pp. 87-89 (Jan. 1963).
Lacey, "Derivatives of Acetoacetic Acid. Parts V and VI", J. Chem. Soc., pp. 839-844 (1954).
Moszew et al., "New Type of Addition of Aromatic Isocyanates to Benzoylacetamide. 1,6-Diaryl Derivatives of Uracil," Zesz. Nauk. Univ. Jagiellon, Pr. Chem. 1969, No. 14, pp. 31-45, C.A. 72:12242e.
Hannon et al., Tetrahedron Letters, 21, 1105 (1980).
Clark et al., "Heterocyclic Studies. Part XIX. Some 6-(Substituted phenyl)-uracil and-thiouracil Derivatives," J. Chem. Soc. (C)., pp. 1945-1948 (1971).
Clark et al., "Heterocyclic Studies. Part XXVII. Mass Spectra of 6-(meta- and para-Substituted-phenyl)-uracil and -thiouracil Derivatives", J. Chem. Soc. Perkin II, pp. 233-237 (1972).
Senda et al., "Pyramidine Derivatives and Related Compounds. 15. Synthesis and Analgetic and Antiinflammatory Activities of 1,3-Substituted 5-Amino-6-Methyluracil Derivatives," J. Med. Chem., vol. 15, No. 5, pp. 471-476 (1972).
Derwent Abstract 62348T-BC.
Ahmed et al., "Purines, Pyrimidines, and Imidazoles. Part XLIV. Syntheses of Some Dihydro-1,3-oxazine Derivatives and Related Substituted Uracils," J.C.S. Perkin I, pp. 1969-1975 (1976).
Yogo et al., "Pyrimidine Derivatives and Related Compounds. 38 (1). Synthesis of 1,3-Oxazine-2,4-diones and Their Reaction with Nucleophiles. Ring Transformation of 1,3-Oxazines to Pyrimidines," J. Heterocyclic Chem. 18, pp. 1095-1100 (Oct. 1981).
Glenn et al., Life Sciences 5: 619 (1966).
C. A. Winter, E. A. Risley, G. W. Nuss, Proc. Soc. Exp. Biol. Med. 111, 544 (1962).
Finney, D. J., (1964) Statistical Method in Biological Assay, Hafner, N.Y.
Boissona, Adv. Org. Chem. 3, 159 (1963).
Windholz et al., Tetrahydron Lett., 8, 2555 (1967).
Skulnick Harvey I.
Smith Herman W.
Smith Robert J.
Wierenga Wendell
Cox Martha A.
Daus Donald G.
Kapner Stephen M.
The Upjohn Company
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