Cholinergic function increasing 3-[N-(pyridyl) carbamoyl]-1,4-di

Details Cholinergic function increasing 3-[N-(pyridyl) carbamoyl]-1,4-di Cholinergic function increasing 3-[N-(pyridyl) carbamoyl]-1,4-di

1984-12-10

1986-03-25

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546262, C07D40112, A61K 31455

Patent

active

045783942

ABSTRACT:
This invention relates to 1,4 dihydropyridines having the following formula ##STR1## wherein R is loweralkyl or Arloweralkyl; R.sub.1, R.sub.2 and R.sub.3 may be the same or different and are hydrogen, loweralkyl or halogen; X is hydrogen, NH.sub.2, ##STR2## and R.sub.4 is hydrogen or loweralkyl. The compounds of this invention display utility in the treatment of Alzheimer's disease and related cognitive disorders characterized by centrally deficient cholinergic function.

REFERENCES:
Bodor, N. et al, "Improved Delivery through Biological Membranes. 13 . . . " J. Med. Chem., 26, 528-534 (1983).
Bodor, N. et al, "Improved Delivery through Biological Membranes. 11 . . . " J. Med. Chem., 26, 313-318 (1983).

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