Process for preparing 3-(4-aminoethoxy-benzoyl) benzo B!-thiophe

Details Process for preparing 3-(4-aminoethoxy-benzoyl) benzo B!-thiophe Process for preparing 3-(4-aminoethoxy-benzoyl) benzo B!-thiophe

1995-08-08

1996-04-30

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 57, C07D33356, C07D33358

Patent

active

055126847

ABSTRACT:
The invention provides a process for preparing 6-alkoxy-3-(4-alkoxyphenyl)benzo B!thiophenes in good yield on a manufacturing scale without generating a thick, potentially yield-reducing, paste. The invention also provides methods for converting a-(-alkoxyphenylthio)-4-alkoxyacetophenones into 6-hydroxy-2-(4-hydroxyphenyl)-3- 4-(2-aminoethoxy)benzoyl!benzo B!thiophen es via acylation of a dialkoxy benzo B!thiophene. Each of these preparations relies on an intramolecular cyclization of a dialkoxy acetophenone derivative to yield a benzo B!thiophene without generating a thick paste that lowers overall yields on a manufacturing scale.

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