Process for producing optically active 1,3-butanediol

Details Process for producing optically active 1,3-butanediol Process for producing optically active 1,3-butanediol

1994-05-23

1996-04-30

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435280, 435822, 435911, C12P 718

Patent

active

055124658

ABSTRACT:
Optically active 1,3-butanediol can be obtained by treating an enantiomorphic mixture of 1,3-butanediol with a microorganism or cells thereof which have been ground, acetone-treated, or lyophilized capable of acting on an enantiomorphic mixture of 1,3-butanediol so as to leave (R)- or (S)-1,3-butanediol as such. Further, optically active 1,3-butanediol can be obtained by treating 4-hydroxy-2-butanone with a microorganism or cells thereof which have been ground, acetone-treated, or lyophilized capable of asymmetrically reducing the 4-hydroxy-2-butanone into (R)- or (S)-1,3-butanediol.

REFERENCES:
ATCC Catalogue of Bacteria, Phages and DNA vectors, pp. 38, 150 (1985).
ATCC Catalogue of Fungi/Yeasts, pp. 104, 350 (1987).
IFO List of Cultures pp. 16, 20, 26, 45-50, 52 (1988).
JCM Catalogue of Strains pp. 63, 118, 119, 121 (1992).
DSM Catalogue of Strain pp. 99, 100 (1989).
C. Neuberg et al. (1918) Biochem. Z., 92:96-110.
Murakami et al., (1980) Bull Chemical Society of Japan 53(5):1356-60.
Levene et al. (1931) J. Biol. Chem. 94:361-366.

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