Process for preparation of iminothiazolidines

Details Process for preparation of iminothiazolidines Process for preparation of iminothiazolidines

1988-12-09

1989-10-31

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564 29, C07D27718

Patent

active

048778800

ABSTRACT:
A process for the preparation of certain iminothiazolidines of the formula ##STR1## in which R is halo, nitro, cyano, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, pentahalomethyl, difluoromethyl, pentafluoroethyl, trifluoromethylthio, difluoromethoxy, trifluoromethoxy, tetrafluoroethoxy, methylsulfonyl, C.sub.1 -C.sub.4 alkyloxyiminomethyl, benzyloxyiminomethyl, 1-(C.sub.1 -C.sub.4)alkyl oxyiminoethyl or 1-benzyloxyiminoethyl; R.sub.1 is hydrogen or halo; R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 haloalkyl; and R.sub.3 and R.sub.4 are independently hydrogen, halo, nitro, cyano, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 fluoroalkoxy or C.sub.1 -C.sub.4 alkylthio, by reacting a thiourea with methanesulfonic acid or trifluoromethanesulfonic acid in an aprotic solvent for a period of time and at a temperature sufficient to achieve cyclization of the thiourea to form said iminothiazolidine.
The thiourea may be prepared by reaction of an N-3-substituted allyl aniline with an arylisothiocyanate.

REFERENCES:
patent: 3804848 (1974-04-01), Behner
patent: 4326876 (1982-04-01), Aoyagi
Dains et al., JACS, vol. 44, pp. 2637-2643.
Cholpankulova et al., Izv. Akad. Nauk Kaz. SSR, Ser. Khim., 1984 (6), pp. 75-81.

Affiliated with

Also associated with

Rating

Process for preparation of iminothiazolidines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparation of iminothiazolidines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparation of iminothiazolidines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-626910