Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-06-03
1989-10-31
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514438, 514532, 514559, 514617, 514622, 514725, A61K 3120, A61K 3141
Patent
active
048778052
ABSTRACT:
Various effects of photoaging or sundamage of skin including impairment of differentiation of epidermal epithelial cells and loss of collagen fibers, abnormal changes in elastic fibers and deterioration of small blood vessels in the dermis of the skin are retarded by applying topically to the epidermis in a maintenance therapy program effective amounts of retinoids including retinoid derivatives and stereoisomers thereof such that epithelial growths are substantially reduced and prevented and the skin substantially regains and maintains its firmness, turgor and elasticity. Moreover, with persistent treatment dermal blood cells and vessels increase and the epidermis and dermis thicken, resulting in improved ability of the skin to sense, resist and recover from irritation or injury. Further, hyperpigmentation, lines and wrinkles due to aging are reduced and prevented. The treatment is particularly useful for human facial skin and preferably applied in amounts insufficient to cause excessive irritation.
REFERENCES:
patent: 3729568 (1973-04-01), Kligman
patent: 3856934 (1974-12-01), Kligman
patent: 3906108 (1975-09-01), Felty
patent: 4603144 (1986-07-01), Kligman
Article--Pawson, B. A. et al., "Retinoids at the Threshold: Their Biological Significance and Therapeutic Potential," Journal of Medicinal Chemistry, 25:1269-1277, (1982).
Symposium Publication--J. H. Saurat, Editor, "Retinoids: New Trends in Research and Therapy", Karger Publishing Company (1-85).
Article--Thomas, J. R., et al., "The Therapeutic Uses of Topical Vitamin A Acid, " Journal of American Academy of Dermatology, 4:505-516, (1981).
Kligman, A. M. et al., "A New Formula for Depigmenting Human Skin", Archives of Dermatology, 111:40-48, (1975).
Kligman, A. M. et al., "Topically Applied Tretinoin for Senile (Solar) Comedones", Archives of Dermatology, 104:420-421, (1971).
Robinson, T. A. et al., "Treatment of Solar Keratoses of the Extremities with Retinoic Acid and 5--Fluorouracil," British Journal of Dermatology, 92:703-705, (1975).
Kligman, L. H. et al., "The Effect of Rhino Mouse Skin of Agents which Influence Keratinization and Exfoliation," Journal of Investigative Dermatology, 73:354-358, (1979).
Saline, C., "Adventures in the Skin Trade," Philadelphia Magazine, pp. 120-133, (1980).
"Industry Happenings," Drug & Cosmetics Industries, p. 86, (1985).
Mayer, H., et al., "Retinoids, A New Class of Compounds with Prophylactic and Therapeutic Activities in Oncology and Dermatology," Experientia, vol. 34, (1978).
Trown, P. W., "Relationship Between Binding Affinities to Cellular Retinoic Acid--Binding Protein and in Vivo and in Vitro Properties for 18 Retinoids," Cancer Research, vol. 40, p. 211, (1980).
LandOfFree
Methods for treatment of sundamaged human skin with retinoids does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for treatment of sundamaged human skin with retinoids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for treatment of sundamaged human skin with retinoids will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-626326