N-Substituted 2-(8-halo and trifluoromethyl 4-quinolylamino)benz

Details N-Substituted 2-(8-halo and trifluoromethyl 4-quinolylamino)benz N-Substituted 2-(8-halo and trifluoromethyl 4-quinolylamino)benz

1980-08-11

1982-11-02

Springer, David B.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546161, C07D21546, C07D40312, A61K 3147

Patent

active

043573339

ABSTRACT:
The disclosure describes new 4-aminoquinoline derivatives of general formula ##STR1## and their pharmaceutically acceptable acid addition salts, where X is trifluoromethyl or halogen, Z is hydrogen or a defined substituent and R is a group having one of the formulae ##STR2## where R.sup.1 is hydrogen or lower alkyl, R.sup.2 is lower alkyl, R.sup.3 is lower alkyl and A is lower alkylene. The new 4-aminoquinoline derivatives show analgesic activity and, in some cases, anti-inflammatory activity.

REFERENCES:
patent: 3174972 (1965-03-01), Allais et al.
patent: 3875165 (1975-04-01), Archibald et al.
patent: 4025629 (1977-05-01), Coverdale

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