Process for preparing 1-alkyl-5-nitroimidazoles

Details Process for preparing 1-alkyl-5-nitroimidazoles Process for preparing 1-alkyl-5-nitroimidazoles

1989-01-13

1990-05-15

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548338, 548339, 548340, C07D23392, C07D40506

Patent

active

049259490

ABSTRACT:
Process for preparing 1-alkyl-5-nitroimidazoles of formula: ##STR1## which comprises reacting an alkyl sulphate with an imidazole derivative of general formula: ##STR2## in an organic solvent, and then hydrolyzing or alcoholyzing the product obtained. In the formulae (I) and (II), R denotes hydrogen, unsubstituted or substituted alkyl, aryl or cycloalkyl. In the formula (I), R.sub.1 denotes alkyl. In the formula (II), X denotes a group which can be removed by hydrolysis or alcoholysis.

REFERENCES:
Fieser, L. et al., Reagents for Organic Synthesis, John Wiley, New York, 1967, pp. 294-295.
Chemical Abstracts, 77:139490t (1972) [D. Tomalia et al., J. Heterocycl. Chem., 1972, 9(4), 891-4].

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