Pyridinyl-1H-pyrazole-1-alkanamides as antiarrhythmic agents

Details Pyridinyl-1H-pyrazole-1-alkanamides as antiarrhythmic agents Pyridinyl-1H-pyrazole-1-alkanamides as antiarrhythmic agents

1989-03-22

1990-05-15

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514333, 514212, 514318, 546256, 546279, 546193, 546194, 540484, C07D40104, A61K 31415

Patent

active

049258575

ABSTRACT:
N-[(alkylamino)alkyl]-4,5-diaryl-1H-pyrazole-1-acetamides, wherein at least one of the aryl substituents is a pyridine, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine.

REFERENCES:
patent: 4072498 (1978-02-01), Moon et al.
patent: 4182895 (1980-01-01), Bailey
patent: 4695566 (1987-09-01), Heinemann et al.
Ezrin et al. FASEB Journal 2, A1557 (1988).

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