Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1988-03-30
1990-05-15
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436529, 436535, 436548, 530387, 530413, 530402, 530813, 530808, 530809, 43524027, 935103, 935108, 935110, G01N 33577, G01N 33535
Patent
active
049257870
ABSTRACT:
A monoclonal anti-idiotypic antibody specific to a human IgG.sub.1 type monoclonal antibody possessing specificity to nicotinic acetylcholine receptor; a method for the production of the aforementioned monoclonal anti-idiotypic antibody by the steps of immunizing an animal with a human IgG.sub.1 type monoclonal antibody specific to nicotinic acetylcholine receptor, collecting antibody-producing cells from the animal, fusing the collected cells with neoplastic cells, selecting from the product of fusion a hybridoma capable of producing a monoclonal anti-idiotypic antibody specific to the human IgG.sub.1 type monoclonal antibody possessing specificity to nicotinic acetylcholine receptor, propagating the selected hybridoma thereby giving rise to said monoclonal anti-idiotypic antibody, and collecting the produced monoclonal anti-idiotypic antibody; and use of the monoclonal anti-idiotypic antibody as a reagent and as an adsorbent.
REFERENCES:
patent: 4536479 (1985-08-01), Vander-Mallie
Lefvert, A. et al., Eur. J. Immunol, 12(9), 790-792, (Sep. 1982)
Mehraban, F. et al., Eur. J. Biochem., 138(1), 53-61, (Jan. 1984).
Nature, (1983), vol. 301, pp. 611-614, "Naturally Occurring Anti-Idiotypic Antibodies in Myasthenia Gravis Patients", Dwyer et al.
Eur. J. Immunol., (1982), vol. 12, pp. 790-792, "A Monoclonal Anti-Idiotypic Antibody Against Anti-Receptor Antibodies From Myasthenic Sera", Lefvert et al.
Nakashima Toshihide
Omura Yoshiaki
Takakura Koichi
Tanihara Masao
Yamada Hideaki
Agency of Industrial Science and Technology
Ministry of International Trade and Industry
Nucker Christine M.
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