Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1987-04-01
1990-05-15
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424 71, 424 852, 424450, 424460, 424461, 424463, 424469, 424488, 424499, 4284022, 42840224, 436829, 514963, 514965, A61K 916, A61K 4505
Patent
active
049256785
ABSTRACT:
This application describes the preparation and in vivo testing of surface coatings and matrix materials, which when applied to or caused to comprise the carriers for drugs and diagnostic agents, and administered in a fashion that allows efficient vascular access, causes the carriers to recognize determinants present or normal or focally diseased endothelium, and induces the following in vivo effects: (1) rapid, partial or total endothelial envelopment of the drug (diagnostic) carrier; (2) sequestration of the carrier and protecting entrapped agent from blood vascular clearance at an early time (2 minutes) when the endothelial pocket which envelops the carrier still invaginates into the vascular compartment; (3) acceleration of the carrier's transport across or through the vascular endothelium and/or subendothelial structures into the tissue compartment (interstitium); and (4) improvement of the efficiency with which the drug (or diagnostic) carrier migrates across the endothelium, or epi-endothelial or subendothelial barriers, such that a lower total drug dose is required to obtain the desired effect relative to that required for standard agents.
REFERENCES:
patent: 4182330 (1980-01-01), Michaels
patent: 4427808 (1984-01-01), Stol et al.
patent: 4432802 (1984-02-01), Harata et al.
patent: 4568536 (1986-02-01), Kronenthal et al.
patent: 4624846 (1986-11-01), Goldenberg
patent: 4671958 (1987-06-01), Rodwell et al.
European Search Report, 10/14/88.
LandOfFree
Endothelial envelopment drug carriers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Endothelial envelopment drug carriers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endothelial envelopment drug carriers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-620657