Intermediates in the process for making histamine antagonists

Details Intermediates in the process for making histamine antagonists Intermediates in the process for making histamine antagonists

1979-04-06

1980-10-07

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424251, 544238, 544295, 544296, C07D23934, A61K 31505

Patent

active

042270006

ABSTRACT:
A process for making substituted 2-aminopyrimidones which are histamine H.sub.2 - antagonists which comprises reacting a 2-nitroaminopyrimidone with a heteroarylalkylamine, heteroarylalkylthioalkylamine, or heteroarylalkoxyalkylamine. One particular compound which can be made by this process is 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-[5-(1,3-benzodioxolyl) methyl]-4-pyrimidone. Also claimed are 2-nitroaminopyrimidone intermediates for use in this process. One specific intermediate is 2-nitroamino-5-[5-(1,3-benzodioxolyl)methyl]-4-pyrimidone.

REFERENCES:
patent: 4116674 (1978-09-01), Sanley et al.
Sirakawa, "J. Pharm. Soc. Japan", vol. 73, (1953), pp. 635-639.
Sirakawa, "Yakugaku Zasshi", vol. 79, (1959), pp. 1477-1482.
Sirakawa, "Yakugaku Zasshi", vol. 79, (1959), pp. 1487-1492.
Bitny-Szlachto, "Acta Polon. Pharm.", vol. 29, (1972), pp. 153-158.

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