Process for halogenation of .beta.-lactam compounds

Details Process for halogenation of .beta.-lactam compounds Process for halogenation of .beta.-lactam compounds

1979-02-01

1980-10-07

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

260239A, 544 21, 544 22, 548153, C07D50104

Patent

active

042269865

ABSTRACT:
Novel halogenating compounds, derived from triaryl phosphites and chlorine or bromine are employed to convert 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the corresponding C-7 imino halide cephem derivatives. The product 3-halo-3-cephems are antibiotic compounds or intermediates thereto.

REFERENCES:
patent: 3925372 (1975-12-01), Chauvette
patent: 3962227 (1976-06-01), Chauvette
patent: 4115643 (1978-09-01), Kukolja et al.

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