Preparation of thiazolo (2,3-b) zuinazolones

Details Preparation of thiazolo (2,3-b) zuinazolones Preparation of thiazolo (2,3-b) zuinazolones

1990-04-12

1991-07-09

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

71 90, C07D23970, A01N 4302

Patent

active

050307274

ABSTRACT:
The process of manufacturing thiazolo-(2,3-b)-quinoazolones of the formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined in the disclosure, wherein either a) an anthranilamide derivative of the formula II ##STR2## where R.sup.5 and R.sup.6 are hydrogen or C.sub.1 -C.sub.4 -alkyl, is reacted with a thiazole derivative of the formula III ##STR3## where X is fluorine, chlorine, bormine, alkylsulfonyl or arylsulfonyl, or b) for certain radicals R.sup.4' from the group R.sup.4 - a thiazolo-(2,3-b)-quinazolone of the general formula IV ##STR4## is reacted with a nucleophile R.sup.4' -H, where R.sup.4' is alkoxy, alkylthio or unsubstituted or halogen-, alkyl-, haloalkyl-, nitro- or alkoxy-substituted phenoxy or thiophenyl, or an alkali metal, alkaline earth metal or ammonium salt of an alcohol.

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Morrison and Boyd, "Organic Chemistry" 3rd, Ed. 1978, p. 829.

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