Sustained release therapeutic compositions

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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424 22, 424 35, 424175, 424362, A61K 4700

Patent

active

042268494

ABSTRACT:
Shaped pharmaceutical tablets, lozenges, suppositories and other solid dosage unit forms which have a prolonged and regular release pattern of a therapeutically active medicament incorporated therein, wherein the shaped dosage unit comprises a carrier base material of hydroxypropylmethylcellulose or a mixture thereof with up to 30% ethylcellulose and/or up to 30% sodium carboxymethylcellulose and wherein the carrier base material is subjected to hydrolysis and oxidation so as to generate thereon a desired minimum concentration of carbonyl and carboxyl groups, and then admixed and shaped with a therapeutically active medicament.

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Forest Laboratories, Inc., Lowey, H. Tablets based on Hydroxypropyl Methyl Cellulose Treated by Adjusting Moisture Content to 85 percent then drying to 5 percent for Continuous Release of Pharmaceutical, DT 2718260, SW 7704764, J 52145514, BR 7702882, FR 2358895.
Lowey H., Slow Release Compnds, based on Hydroxypropylmethyl Cellulose, NL 7308859-DT 2332484-FR 2190409-J 49054519-GB 1430684.

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