Preparation of 5,8,13,14-tetrahydrobenz[5,6]isoindolo[2,1-b]isoq

Details Preparation of 5,8,13,14-tetrahydrobenz[5,6]isoindolo[2,1-b]isoq Preparation of 5,8,13,14-tetrahydrobenz[5,6]isoindolo[2,1-b]isoq

1989-01-06

1990-06-12

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 42, C07D47104

Patent

active

049334573

ABSTRACT:
A process is described for the preparation of compounds of formula (1) ##STR1## [where OR is hydroxyl, protected hydroxyl or OP(O)(OCH.sub.2 Ph)(OR.sup.1) (where Ph is phenyl and OR.sup.1 is hydroxyl or protected hydroxyl)] and salts thereof, which comprises reacting a compound of formula (2) ##STR2## with a compound of formula (3) ##STR3## (where OR is as defined above and one of X.sup.1 and X.sup.2 is a leaving group and the other is a hydrogen atom) or a salt thereof, followed, if desired, by removal of the hydroxyl protecting group when present and/or by salt formation.
The compounds of formula (1) are either anticancer agents or intermediates useful in the synthesis of anticancer agents.

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