Thiazole derivatives, their preparation and their use in the tre

Details Thiazole derivatives, their preparation and their use in the tre Thiazole derivatives, their preparation and their use in the tre

1989-04-13

1990-06-12

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 5142278, 5142368, 514255, 514326, 540603, 544 60, 544133, 544367, 546209, 548183, C07D41706, A61K 31425

Patent

active

049333550

ABSTRACT:
Compounds of formula (I): ##STR1## in which: R.sup.1 and R.sup.2 are independently hydrogen, alkyl, aliphatic hydrocarbon groups having one or two carbon-carbon double or treble bonds, cycloalkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, alkanoyl, alkenyol, cycloalkylcarbonyol, arylcarbonyl, substituted arylcarbonyl, arylalkanoyl, substituted arylalkanoyl, arylalkenoyl, substituted arylalkenoyl, alkoxycarbonyl, aryloxycarbonyl, substituted aryloxycarbonyl, aralkyloxycarbonyl, substituted aralkyloxycarbonyl, optionally substituted carbamoyl or thiocarbamoyol, alkylsulfonyl, haloalkylsulfonyl, arylsulfonyl, substituted arylsulfonyl, alkylthio, arylthio and substituted arylthio, or R.sup.1 and R.sup.2, together with the nitrogen atom to which they are attached, form a nitrogen-containing heterocyclic group; one of R.sup.a and R.sup.b is hydrogen, alkyl or halogen, and the other of R.sup.a and R.sup.b is a group of formula (II): ##STR2## R.sup.4 is hydrogen, carboxy, protected carboxy or optionally substituted carbamoyl; R.sup.5 is hydrogen, or carboxyalkyl or protected carboxyalkyl in which the alkyl part is C.sub.1 -C.sub.6 ; n=0, 1 or 2; X is oxygen or sulfur; are useful in the treatment of the complications attendant upon diabetes and may be prepared by condensation of a thiazolidine or rhodanine compound with a compound corresponding to the remainder of the molecule of the compound of formula (I).

REFERENCES:
patent: 4831045 (1989-05-01), Tanouchi

Affiliated with

Also associated with

Rating

Thiazole derivatives, their preparation and their use in the tre does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thiazole derivatives, their preparation and their use in the tre, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiazole derivatives, their preparation and their use in the tre will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-617520