Phenolic thioethers, sulfoxides, and disulfides as inhibitors of

Details Phenolic thioethers, sulfoxides, and disulfides as inhibitors of Phenolic thioethers, sulfoxides, and disulfides as inhibitors of

1989-07-11

1991-03-26

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514460, 514532, 514570, 514826, 549273, 549323, 560 9, 560 11, 560 17, 562426, 562429, 562431, A61K 3119, A61K 3134, A61K 3135, A61K 31235

Patent

active

050029673

ABSTRACT:
The compounds of the present invention comprise substituted phenolic thioethers, sulfoxides, and disulfides that are specific inhibitors of 5-lipoxygenase and which, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metablic pathway are involved.

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