Photosensitizing agents

Details Photosensitizing agents Photosensitizing agents

1988-07-20

1991-03-26

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540145, A61K 3140, C07D48722

Patent

active

050029622

ABSTRACT:
New classes of photosensitizing compounds useful in photodynamic therapy are disclosed. These compounds are simplified dimers and polymers of monohydroxy deuteroporphyrins, hydrophobic ethers of these monomers, and red light-absorbing derivatives of methyl pheophorbide-a.

REFERENCES:
patent: 4649151 (1987-03-01), Dougherty et al.
Karasawa et al., Chemical Abstracts, vol. 110 (1989) 94862x.
Dougherty et al., Adv. Exp. Med. Biol. (1983) 160:3-13.
Kessel et al., Photochem. Photo. Biol. (1987) 46:463-568.
Lipson et al., J. Natl. Cancer Inst. (1961) 26:1-8.
Pandey et al., Cancer Res.
Scourides et al., Cancer res. (1987) 47:3439-3445.
Photochemistry and Photobiology, vol. 46, No. 5, 1987 Eva M. Beems et al., "Photosensitizing Properties of Bacteriochlorophyllin a and Bacteriochlorin a, Two Derivatives of Bacteriochlorophyll a," pp. 639-643.

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