N-haloalkyl-4-(isoxazol-5-yl)alkoxy benzamides

Details N-haloalkyl-4-(isoxazol-5-yl)alkoxy benzamides N-haloalkyl-4-(isoxazol-5-yl)alkoxy benzamides

1989-06-12

1991-03-26

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544 88, 544 96, 548206, 548214, 548237, 548247, 548235, 558423, 558425, 560 65, 562474, 562840, 564177, A61K 3142, C07D26108, C07D41310, C07D41710

Patent

active

050029606

ABSTRACT:
Compounds of the formulas: ##STR1## wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed. Also disclosed are novel intermediates, N-halo-alkyl-4-(isoxazol-5-yl)alkoxybenzamides, also useful as antiviral agents.

REFERENCES:
patent: 4268678 (1981-05-01), Diana et al.
patent: 4451476 (1984-05-01), Diana
patent: 4843087 (1989-06-01), Diana
patent: 4857539 (1989-08-01), Diana et al.
Diana et al., Chemical Abstracts, vol. 106, No. 138429 (1987) (Abstract for EP 207454, 1/7/87).

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