Epoxy steroids

Details Epoxy steroids Epoxy steroids

1985-06-13

1987-06-02

Schenkman, Leonard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

A61K 3158, C07J 7100

Patent

active

046705511

ABSTRACT:
7.alpha.-acylthio-9.alpha.,11.alpha.-epoxy-20-spirox-4-ene-3,21-diones of the formula I ##STR1## in which R represents lower alkanoyl and --A--A-- represents an ethylene or cyclopropylene group, have a high aldosterone-antagonistic activity without significant sexually-specific side-effects and can be used as potassium-protecting diuretics in the treatment of various forms of hyperaldosteronism. The compounds can be obtained by conventional processes of steroid chemistry.

REFERENCES:
patent: 4559331 (1985-12-01), Nickisch et al.
patent: 4559332 (1985-12-01), Grob et al.
Fieser & Fieser: Steroids; p. 708 (Reinhold Publ. Corporation New York, New York).
Merck Index, 10th Edition, 8610; p. 1254; Merck & Company Rahway, New Jersey, 1983.
Chemical Abstracts, vol. 79, (1973), Abstr. No. 105,471.
Tetrahedron Letters 21: pp. 4163-4166 (1980).
Tetrahedron Letters 23: pp. 167-170 (1982).

Affiliated with

Also associated with

Rating

Epoxy steroids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Epoxy steroids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Epoxy steroids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-614868