Ergoline derivatives

Details Ergoline derivatives Ergoline derivatives

1982-11-01

1985-02-19

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 68, C07D45704, A61K 3148

Patent

active

045007128

ABSTRACT:
There are provided ergoline derivatives of formula ##STR1## wherein R.sub.1 .dbd.H, CH.sub.3 ; R.sub.2 .dbd.H or halogen atom, or CH.sub.3,CN, alkyl- or phenyl-thio; R.sub.3 .dbd.H, OCH.sub.3 ; R.sub.4 .dbd.C.sub.1 -C.sub.4 hydrocarbon group; X.dbd.O, S, NH; A.dbd.CO, SO.sub.2 ; B.dbd.C.sub.1 -C.sub.4 hydrocarbon group, aryl, aralkyl, heterocyclic ring group, alkoxy, aryloxy; n.dbd.0, 1, 2; and pharmaceutically acceptable salts thereof.
A process for preparing said compounds is also provided. The compounds show anti-hypertensive activity and are active on the gastroenteric system.

REFERENCES:
patent: 3717640 (1973-02-01), Arcari et al.
patent: 3732231 (1973-05-01), Semonsky et al.
patent: 3821226 (1974-06-01), Fehr et al.
patent: 3966941 (1976-06-01), Semonsky et al.
patent: 4201862 (1980-05-01), Kornfeld et al.
patent: 4235912 (1980-11-01), Rettegi et al.

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