5-Oxo-5H-(1)benzopyrano(2,3-b)pyridine derivatives, their produc

Details 5-Oxo-5H-(1)benzopyrano(2,3-b)pyridine derivatives, their produc 5-Oxo-5H-(1)benzopyrano(2,3-b)pyridine derivatives, their produc

1983-07-05

1985-09-03

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514291, 546 89, 546 77, 546 92, 546 62, C07D49100, C07D22118, C07D47100, A61K 31435

Patent

active

045393265

ABSTRACT:
The present invention relates to novel 5-oxo-5H-[1]benzopyrano[2,3-b]pyridine derivatives useful for effective medicines for the treatment of various connective tissue diseases such as chronic rheumatoid arthritis and varieties of inflammatory diseases caused by immunoreaction, which have the following formula: ##STR1## wherein R is the same or different and represents hydrogen, alkyl, alkoxy, nitro, hydroxyl, acyl, hydroxyalkyl, halogen with the proviso that m is 1,2 or 3, or a tetramethylene (--(CH.sub.2).sub.4 --) or butadienylene (--CH.dbd.CH--CH.dbd.CH--) group which, in conjunction with two adjacent carbon atoms on the ring, forms a six-membered ring with the proviso that m is 1; n is 1 or 2, or a physiologically acceptable salt or ester thereof.

REFERENCES:
patent: 3931199 (1976-01-01), Nakanishi et al.
patent: 3931205 (1976-01-01), Nakanishi et al.
patent: 4143042 (1979-03-01), Nohara et al.
patent: 4255576 (1981-03-01), Nohara et al.
patent: 4299963 (1981-11-01), Nohara et al.
patent: 4302463 (1981-11-01), Ishiguro et al.
Liebig Ann. Chem. 1976, 1659-1662.

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