Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones

Details Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones

1984-10-01

1985-09-03

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514215, 514237, 514318, 514332, 514335, 514340, 514343, 514351, 514357, 546194, 546256, 546261, 546264, 546296, 546300, 546281, 546272, 546275, 546334, 544 60, 544124, C07D21363, C07D21350, C07D40106, A61K 3144

Patent

active

045393168

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.12 is a leaving group, Z is S, O or CH.sub.2 and A is a phenyl, furyl, thienyl or pyridyl ring substituted by a ##STR2## moiety, in which R.sup.8 and R.sup.9 are various substituents or, when taken together with the nitrogen, may be a specified heterocyclic ring, are intermediates in the preparation of histamine H.sub.2 -antagonist anti-ulcer agents of the formula ##STR3## in which R.sup.1 and R.sup.2 are any of several specified substituents.

REFERENCES:
patent: 4062863 (1977-12-01), Ganellin et al.
patent: 4233302 (1980-11-01), Martin-Smith et al.
patent: 4242350 (1980-12-01), Yellin et al.
patent: 4242351 (1980-12-01), Yellin et al.

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