Antiviral pyridazine hydrazones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514252, 514253, 544238, 544239, A61K 3150, C07D40112, C07D40312, C07D40512

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active

046704370

ABSTRACT:
This invention provides antiviral pyridazinyl hydrazones of the formula ##STR1## wherein when taken singly, R is H, CH.sub.3 or C.sub.2 H.sub.5 ; and R.sup.1 is thienyl, halothienyl, pyridyl, methylthienyl, furyl, indolyl, tolyl, xylyl, biphenyl, C.sub.1 -C.sub.4 alkoxyphenyl, 1-adamantyl and, when R is other than H, methyl; R and R.sup.1 taken together form a 2-adamantindinyl group; and R.sup.3 is a C.sub.4 -C.sub.6 tertiary alkyl group attached through a tertiary carbon to the pyridazine ring, such as t-butyl, 1,1-dimethylethyl, 1,1-dimethylpropyl, or 1-methyl-1-ethylpropyl, and mineral acid addition salts thereof.

REFERENCES:
Schauer et al., Proc. Int. Conf. Chemotherapy, 72, 329-331 (1972)
Likar et al., J. Med. Chem., 14, 246 (1971).
Japelj et al., Il. Farmaco. Ed. Sci., 28, 116 (1973).
Steiner et al., J. Med. Chem., 24, 59 (1981).
Matyus et al., Acta Chim. Acad. Sci. Hung., 106, 205 (1981).
Shams et al., Ind. J. Chem., 21B, 317 (1982).
How et al, Chem. Abs., 85, 192643m (1976).
Miyazawa, Chem. Abs. 63, 3477e (and index sheet).

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