Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-09-11
1987-06-02
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514252, 514253, 544238, 544239, A61K 3150, C07D40112, C07D40312, C07D40512
Patent
active
046704370
ABSTRACT:
This invention provides antiviral pyridazinyl hydrazones of the formula ##STR1## wherein when taken singly, R is H, CH.sub.3 or C.sub.2 H.sub.5 ; and R.sup.1 is thienyl, halothienyl, pyridyl, methylthienyl, furyl, indolyl, tolyl, xylyl, biphenyl, C.sub.1 -C.sub.4 alkoxyphenyl, 1-adamantyl and, when R is other than H, methyl; R and R.sup.1 taken together form a 2-adamantindinyl group; and R.sup.3 is a C.sub.4 -C.sub.6 tertiary alkyl group attached through a tertiary carbon to the pyridazine ring, such as t-butyl, 1,1-dimethylethyl, 1,1-dimethylpropyl, or 1-methyl-1-ethylpropyl, and mineral acid addition salts thereof.
REFERENCES:
Schauer et al., Proc. Int. Conf. Chemotherapy, 72, 329-331 (1972)
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Japelj et al., Il. Farmaco. Ed. Sci., 28, 116 (1973).
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Miyazawa, Chem. Abs. 63, 3477e (and index sheet).
Barclay Bruce J.
Berch Mark L.
Eli Lilly and Company
Whitaker Leroy
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