Mucopolysaccharides having biological properties, preparation an

Details Mucopolysaccharides having biological properties, preparation an Mucopolysaccharides having biological properties, preparation an

1981-11-20

1985-02-19

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 21, 514822, A61K 31725, C08B 3710

Patent

active

045005192

ABSTRACT:
Mucopolysaccharides biologically active and more specific than heparin, particularly with respect to the blood factor Xa. These mucopolysaccharides may be obtained by partial depolymerisation, under controlled conditions, of heparin, by the action of a chemical agent such as nitrous acid. The conditions implemented allow the preparation of mucopolysaccharides having a USP titer lower than that of the starting heparin and a Yin-Wessler titer at least equal to that of said heparin. These products may be used particularly as antithrombotic drugs.

REFERENCES:
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patent: 4122250 (1978-10-01), Schmer
patent: 4168377 (1979-09-01), Choay et al.
patent: 4175182 (1979-11-01), Schmer
patent: 4281108 (1981-07-01), Fussi
patent: 4303651 (1981-12-01), Lindahl et al.
patent: 4351938 (1982-09-01), Barnett

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