Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1982-05-05
1985-02-19
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Lymphokine
A61K 39275
Patent
active
045005125
ABSTRACT:
The stabilizing agent is constituted by a phosphate buffer solution (PBS) containing calcium and magnesium ions, which contains in addition lactose, sorbitol and at least one amino acid taken from the group which comprises histidine, alanine, valine, threonine, arginine, methionine, hydroxyproline, lysine, isoleucine, phenylalanine, serine, and preferably constituted by an association of histidine and alanine. The stabilized vaccine is constituted by a suspension of live attenuated viruses in the above stabilizing agent, and lyophilized. The invention also relates to the method for preparing such a stabilized vaccine, to the stabilized vaccines so-obtained and to their use for treating viral diseases in humans or animals.
REFERENCES:
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Robin et al., Bull. WHO 44:729-737 (1971)(FR), Study of the Heat Stability of Anti-yellow Fever Vaccine in Samples of Eight Batches from Various Countries.
Finter et al., Dev. Biol. Stand. 36:279-283 (1977), Long Term Storage Studies with a New Stabilized Formulation of Yellow Fever Virus Vaccine.
Finter et al., Dev. Biol. Stand. 41:271-276 (1978), Effects of Adverse Storage on Live Virus Vaccines.
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McAleer, W. J. et al., "Stability on Storage at Various Temperatures of Live Measles, Mumps and Rubella Virus Vaccines in New Stabilizer", Journal of Biological Standardization, 8, 281-287 (1980).
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Institut Pasteur
Rose Shep K.
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