Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1984-07-31
1985-09-03
Roberts, Elbert L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
C07J 900
Patent
active
045391530
ABSTRACT:
The invention relates to a method of preparing 1 .alpha.-hydroxyvitamin D or 1 .alpha.-hydroxy-previtamin D compounds by hydroxylating the 1 .alpha.-position of an adduct of a previtamin D compound with a suitable dienophile, in which adduct optionally present hydroxy group or hydroxy groups is or are protected, if desired, and after removal of the protecting group or groups, isolating the 1 .alpha.-hydroxyvitamin D or 1 .alpha.-hydroxy-previtamin D compound.
The invention also relates to 1 .alpha.-hydroxy-previtamin D compounds.
The invention further relates to an adduct of a previtamin D or tachysterol compound with a dienophile of the general formula ##STR1## in which A' and B' are equal and represent methoxy groups or ethoxy groups, or in which A' and B' together constitute a phenylimino or o-phenylene group.
REFERENCES:
patent: 3901928 (1975-08-01), Hesse et al.
patent: 4022768 (1977-05-01), Matsunaga et al.
patent: 4110446 (1978-08-01), De Luca et al.
patent: 4202829 (1980-05-01), De Luca et al.
patent: 4335120 (1982-06-01), Holick et al.
De Clercq Pierre J.
Halkes Sebastianus J.
Overbeek Wilhelmus R. M.
Vandewalle Maurits
Vanmaele Luc J.
Duphar International Research B.V.
Roberts Elbert L.
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