Method of producing 2-epi-fortimicin A

Details Method of producing 2-epi-fortimicin A Method of producing 2-epi-fortimicin A

1982-04-09

1983-11-29

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1522

Patent

active

044181930

ABSTRACT:
An improved method of producing 2-epi-fortimicin A directly from fortimicin A by protecting the amine functions of fortimicin A, converting the N-protected fortimicin A to an intermediate of the formula: ##STR1## wherein L is a leaving group and Z is an amine-protecting group, reacting the intermediate (I) with a loweralkyl metal halide in N,N-dimethylformamide to form N-protected-2-epi-fortimicin A, and then hydrogenating the N-protected-2-epi-fortimicin A to obtain 2-epi-fortimicin A.

REFERENCES:
patent: 4207415 (1980-06-01), Carney et al.
patent: 4272626 (1981-06-01), Carney et al.
patent: 4273924 (1981-06-01), Martin et al.
patent: 4331804 (1982-05-01), Tadanier et al.

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