Thiazolidine prodrugs for the improved delivery of anti-inflamma

Details Thiazolidine prodrugs for the improved delivery of anti-inflamma Thiazolidine prodrugs for the improved delivery of anti-inflamma

1979-07-24

1980-12-16

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602395, C07J 7100

Patent

active

042397570

ABSTRACT:
Novel 3,2'-spiro(1',3'-thiazolidine) compounds which are transient prodrug forms of known anti-inflammatory corticosteroids are disclosed. The subject compounds can be prepared by known methods, for example, by reacting the corresponding 3-keto steroids with a thiazolidine forming reagent such as an L-cysteine alkyl ester. Preferred compounds are derived from such known anti-inflammatory corticosteroids as cortisone acetate, hydrocortisone, prednisone, prednisolone and the like.

REFERENCES:
patent: 3542770 (1970-11-01), Dekono
patent: 3562255 (1971-02-01), Oliver et al.
patent: 3676426 (1972-07-01), Clinton

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