Substituted guanidine derivatives, processes, pharmaceutical com

Details Substituted guanidine derivatives, processes, pharmaceutical com Substituted guanidine derivatives, processes, pharmaceutical com

1981-07-23

1984-08-07

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544194, 544224, 544326, 544328, 544329, 546306, 548138, 548143, 548193, 548214, 548233, 548246, 548266, 548315, 548376, 564239, C07D27738, C07D23942, A61K 31425, A61K 31505

Patent

active

044643748

ABSTRACT:
The invention relates to a guanidine derivative of the formula: ##STR1## in which W is a 2-6C alkylene chain optionally substituted by 1 or 2 1-4C alkyls; E is O, S, SO, SO.sub.2 or NR.sup.3 in which R.sup.3 is H or 1-6C alkyl; R.sup.1 is H or a straight chain 1-6C alkyl optionally substituted by 1 or 2 1-4C alkyls; or R.sup.1 and R.sup.3 are joined to form a morpholine, pyrrolidine, piperidine or piperazine ring; X, P, Y, Q and R.sup.2 are as defined in the specification, and the pharmaceutically-acceptable acid-addition salts thereof. Manufacturing process, pharmaceutical compositions and intermediates are also described. The compounds of the formula I are histamine H-2 antagonists.

REFERENCES:
patent: 4362728 (1982-12-01), Yellin

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