Photochemical decontamination treatment of whole blood or blood

Details Photochemical decontamination treatment of whole blood or blood Photochemical decontamination treatment of whole blood or blood

1985-10-07

1988-02-23

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

530380, 530381, 530382, 530385, 530386, 530387, 530388, 530392, 530393, 530347, 514 2, 514 6, 424 88, 424 89, 424 92, 424101, 422 24, 422 28, 422 29, 426234, 426318, C12N 1300, C07K 1300, A61K 3900, C07G 700

Patent

active

047270276

ABSTRACT:
Biological compositions are decontaminated by treatment with furocoumarin derivatives and irradiation under particular conditions in which the proteins retain their original physiological activities and any pathogenic microorganisms and polynucleotide fragments thereof are rendered inactive. It has been found that reduction of the amount of dissolved oxygen in the treatment solution substantially inhibits denaturation of the proteins.

REFERENCES:
patent: 4124598 (1978-11-01), Hearst et al.
patent: 4169204 (1979-09-01), Hearst et al.
patent: 4321919 (1982-03-01), Edelson
patent: 4327086 (1982-04-01), Fukushima et al.
patent: 4568542 (1986-02-01), Kronenberg
patent: 4595653 (1986-06-01), Kronenberg
deMol and van Henegouwen (1981) Photochem. Photobiol. 33:815-819.
deMol et al. (1981) Photochem. Photobiol. 34:661-666.
Joshi and Pathak (1983) Biochem. Biophys. Res. Comm., 112:638-646.
Grossweiner (1982) NCI Monograph No. 66, 47-54.
Rodighiero and Dall'Acqua (1982), NCI Monograph No. 66, 31-40.
deMol et al. (1981) 95:74462k, p. 74467 Chem. Interactions.
Hyde and Hearst (1978) Biochemistry 17:1251-1257.
Hanson et al. (1978), J. Gen. Virol. 40:345-358.
Swanstrom et al. (1981), Virol. 113:613-622.
Redfield et al. (1981), Infec. and Immun. 32:1216-1226.
Hanson "Inactivation of Viruses for Use as Vaccines . . . Med. Virol., II, de la Maza & Peterson, eds.
Cremer et al., (1982) J. Clin, Microbiol., 15:815-823.
Veronese, F. M., et al., (1981), Photochem. Photobiol. 34:351.
Veronese et al. (1982), Photochem. Photobiol. 36:25.
Singh and Vadasz (1978) Photochem. Photobiol. 28:539-545.
Musajo et al, Experentia, vol. XXI, pp. 22-24, "Photosensitizing Furocovmanhs-Interaction with DNA and Photoinactivation of DNA Containing Viruses".

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