Substituted azabicycloheptanes, the use thereof, pharmaceutical

Details Substituted azabicycloheptanes, the use thereof, pharmaceutical Substituted azabicycloheptanes, the use thereof, pharmaceutical

1987-04-01

1988-08-16

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 48, 560 12, 260544N, 260545R, 260544F, 556418, 544466, 562430, C07C101447

Patent

active

047646403

ABSTRACT:
1-phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

REFERENCES:
patent: 2673205 (1954-03-01), Hoffmann et al.
patent: 2848455 (1958-08-01), Hoffmann et al.
A. Alder, et al. Helv. Chim. Acta 65: p. 2405 (1982).
A. Alder, et al. J. Am. Chem. Soc. 105: p. 6712 (1983).

Affiliated with

Also associated with

Rating

Substituted azabicycloheptanes, the use thereof, pharmaceutical does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted azabicycloheptanes, the use thereof, pharmaceutical , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted azabicycloheptanes, the use thereof, pharmaceutical will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-601617