Thiazolo[3,4-b]isoquinoline derivatives and pharmaceutical compo

Details Thiazolo[3,4-b]isoquinoline derivatives and pharmaceutical compo Thiazolo[3,4-b]isoquinoline derivatives and pharmaceutical compo

1976-08-05

1977-12-20

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260288CF, 260283S, 260283CN, 260289C, 260289D, 260287D, 260286R, 260283R, 2602948R, C07D51314, A61K 3147

Patent

active

040642470

ABSTRACT:
Thiazolo[3,4-b]isoquinoline derivatives of the general formula: ##STR1## wherein A represents 3-pyridyl, 4-pyridyl or 5-isoquinolyl and, when A represents 3-pyridyl, X.sub.1 represents hydrogen, halogen, dimethylamino or cyano, X.sub.2 represents hydrogen or fluorine and X.sub.3 represents hydrogen or nitro, at least two of X.sub.1, X.sub.2 and X.sub.3 representing hydrogen, or X.sub.1 X.sub.2 together represent methylenedioxy and X.sub.3 represents hydrogen, and when A represents 4-pyridyl or 5-isoquinolyl, X.sub.1, X.sub.2 and X.sub.3 each represent hydrogen, and non-toxic pharmaceutically acceptable acid addition salts thereof, possess useful pharmacodynamic properties, in particular analgesic and antipyretic activity. This invention relates to new therapeutically useful thiazolo[3,4-b]isoquinoline derivatives, to processes for their preparation and to pharmaceutical compositions containing them.

REFERENCES:
patent: 3455933 (1969-07-01), Georgiadis et al.
patent: 3979397 (1976-09-01), Harsanyi et al.

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