Olefinically unsaturated substituents at C-11 of steroid cycliza

Details Olefinically unsaturated substituents at C-11 of steroid cycliza Olefinically unsaturated substituents at C-11 of steroid cycliza

1975-04-28

1977-12-20

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260514L, 2603409AS, 260586R, 2603407, 260327M, 260526R, 260601R, 260580, 260514G, 260397, 2603973, 260632R, 560203, 560190, 560174, 560205, 560192, C07C 3506

Patent

active

040641856

ABSTRACT:
Compositions are provided as well as methods for preparing the compositions which serve as cyclization precursors for the preparation of C-11 alkenyl substituted steroids and nor-steroids. The alkenyl group may be converted after cyclization to a variety of heterosubstituents to provide heterofunctionalized C-11 steroids and nor-steroids. The compounds are provided having an initiator group, which has a chalcoxy atom in juxtaposition to a double bond, an olefinically unsaturated linking group and a terminating group which acts to from a carbocation which reacts with a nucleophile to provide a stable product. The C-11 substituent is found to provide upon cyclization the alpha-configuration, so that the subject compounds provide a direct route to the difficultly accessible alpha-C-11 substituted steroids, or, if desired, the alpha-configuration can be inverted to the beta-configuration.

REFERENCES:
patent: 3741987 (1973-07-01), Johnson et al.
patent: 3904698 (1975-09-01), Johnson et al.
Johnson et al., J.A.C.S., vol. 93(17), pp. 4332-4334 (1971).
Johnson et al., J.A.C.S., vol. 92(3), pp. 741-742 (1970).

Affiliated with

Also associated with

Rating

Olefinically unsaturated substituents at C-11 of steroid cycliza does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Olefinically unsaturated substituents at C-11 of steroid cycliza, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Olefinically unsaturated substituents at C-11 of steroid cycliza will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-599835