Blood substitute based on hemoglobin

Details Blood substitute based on hemoglobin Blood substitute based on hemoglobin

1976-10-08

1977-12-20

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112B, 424177, A23J 106, A61K 31735

Patent

active

040641180

ABSTRACT:
A blood substitute or blood extender is prepared by chemically coupling hemoglobin with a polysaccharide material selected from dextran and hydroxyethyl starch, and having a molecular weight of from about 5,000 to about 2,000,000, to form a covalently bonded chemical complex. The complex has similar oxygen transporting abilities to hemoglobin, and has a much lower rate of renal excretion.

REFERENCES:
patent: 3925344 (1975-12-01), Mazur
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4001401 (1977-01-01), Bonsen et al.
Foerster et al., Chemical Abstracts, vol. 82:11,061q, (1975).
Kaplan et al., Chemical Abstracts, vol. 83:53,540w, (1975).

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