Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines

Details Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines

1994-05-13

1995-10-17

Fan, Jane

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40102

Patent

active

054592747

ABSTRACT:
The synthesis of memory enhancing, analgetic, and antidepressant N-alkyl-N-pyridinyl-1H-indol-1-amines is described.

REFERENCES:
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patent: 4970218 (1990-11-01), Effland
patent: 5032599 (1991-07-01), Effland
patent: 5039811 (1991-08-01), Effland
J. C. Powers, Journal of Organic Chemistry, 31, 2627 (1966) entitled "Chloroindoles" and published in the USA.
M. Somei and M. Natsume, Tetrahedron Letters, 461 (1974), entitled "1-Aminoindoles" and published in Great Britain.
M. R. Brennan, et al., Heterocycles, 24, 2879 (1986), entitled "The Preparation And Spectral Characterization of 2-Haloindoles, 3-Haloindoles, and 2,3-Dihaloindoles" and published in Japan.
G. M. Shutske, Medicinal Chemistry Approaches to Alzheimer's Disease and Other Dementias Symposium, Division of Educational Service, Mayo Clinic, Jacksonville, Jacksonville, Fla., Sep. 13, 1993.
M. Somei, et al., Chemical and Pharmaceutical Bulletin, 26, 2522 (1978), entitled "A Novel N-Amination Method and Its Application To the Preparation of N-Aminoheterocycles" and published in Japan.
D. L. Comins and M. O. Killpack, Tetrahedron Letters, 30, 4337 (1989), entitled "N-Methyl Lithiation of n-Methylindoles Directed By alpha-Amino Alkoxides" & published in the United Kingdom.

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