Process for the production of cephalosporines and novel intermed

Details Process for the production of cephalosporines and novel intermed Process for the production of cephalosporines and novel intermed

1995-05-05

1997-07-01

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540222, C07D50120, C07D49808, A61K 31545

Patent

active

056440529

ABSTRACT:
The invention relates to a new economical and simple process, using a new intermediate compound, for the production of 3'-substituted 7-amino-3-propenyl-4-cephem-carboxylic acid derivatives of formula ##STR1## wherein R is hydrogen, a negative charge or a silyl protecting group, R.sub.o is hydrogen or methoxy, R.sub.1 is hydrogen or a silyl protecting group and X is the radical of a nucleophile, and their acid addition salts.

REFERENCES:
patent: 4112084 (1978-09-01), Plum et al.
patent: 4139618 (1979-02-01), Beeby
patent: 4661590 (1987-04-01), Hoshi
J. Antibiotics 43, 533 (1990).

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