Process for the preparation of phenylbenzamide derivatives

Details Process for the preparation of phenylbenzamide derivatives Process for the preparation of phenylbenzamide derivatives

1994-02-08

1995-10-17

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

564169, 564171, C07C23112, C07D295192

Patent

active

054592623

ABSTRACT:
A new process for the preparation of a phenylbenzamide derivative of the formula ##STR1## wherein R is C.sub.1 -C.sub.2 alkyl, substituted with 2 to 5 F, and each of R.sub.1 and R.sub.2, which can be identical or different, is methyl or ethyl, or --NR.sub.1 R.sub.2 is morpholino, comprising condensing a haloenone (I) with an acetoamide (II), according to scheme ##STR2## in the presence of an organic solvent and 1 to 2 equivalents of base, followed by converting the resulting product in two steps, one of which is a reduction, to the corresponding compound of formula (A). Phenylbenzamides of formula (A) are agricultural fungicides. The new process is suited to large-scale production of these compounds.

REFERENCES:
Das et al, J. Chem. Soc., Dalton Trans. (JCDTBI), 7, pp. 662-664 (1977).
Das et al, Australian Journal of Chemistry, vol. 27, pp. 1177-1183 (1974).

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