Treatment of skin keratoses with .alpha.-hydroxy acids and relat

Details Treatment of skin keratoses with .alpha.-hydroxy acids and relat Treatment of skin keratoses with .alpha.-hydroxy acids and relat

1978-10-04

1980-11-18

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Synthetic or structurally-modified peptidoglycan or...

424283, 424285, 424311, 424316, 424317, 424318, 424320, 424325, 424329, A61K 31335, A61K 3116

Patent

active

042345995

ABSTRACT:
Preventive as well as therapeutic treatment to alleviate the symptoms of skin keratoses consisting of topical application of a solution, gel, lotion, cream or ointment containing one or more of the .alpha.- or .beta.-hydroxy acids or .alpha.-keto acids, esters thereof, and their amine salts is disclosed. The compounds include free acid or amine salt forms of .alpha.-hydroxy-butyric acid, .alpha.-hydroxyisobutyric acid, .alpha.-hydroxyisocaproic acid, .alpha.-hydroxyisovaleric, atrolactic acid, .beta.-hydroxybutyric acid, .beta.-phenyl lactic acid, .beta.-phenylpyruvic acid, citric acid, ethyl pyruvate, galacturonic acid, glucoheptonic acid, glucoheptono 1,4-lactone, gluconic acid, gluconolactone, glucuronic acid, glucuronolactone, glycolic acid, isopropyl pyruvate, lactic acid, malic acid, mandelic acid, methyl pyruvate, mucic acid, pyruvic acid, saccharic acid, saccharic acid 1,4-lactone, tartaric acid, and tartronic acid. The therapeutic composition may include one or more of the compounds present in the total amount of from three to thirty percent. Topical application to affected areas has been found to achieve from substantial to complete remissions of the keratoses in humans.

REFERENCES:
patent: 3666863 (1972-05-01), Swanbeck
patent: 3988470 (1976-10-01), Van Scott et al.
patent: 4105783 (1978-08-01), Yu et al.
Handbook of New Prescription Drugs-5th ed., 1977.

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