Thieno[2,3-d]oxazines

Details Thieno[2,3-d]oxazines Thieno[2,3-d]oxazines

1979-03-30

1980-11-18

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 91, A61K 3138, C07D49804

Patent

active

042345812

ABSTRACT:
2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yields thieno[2,3-d]pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate hypersensitivity reaction in mammals are N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]oxamic acid, ethyl 5,6,7,8-tetrahydro-4-oxo-4H-benzothieno[2,3-d][1,3]oxazine-2-carboxylate, and ethyl 3,4-dihydro-6-ethyl-4-oxothieno[2,3-d]pyrimidine-2-carboxylate.

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patent: 4159377 (1979-06-01), Temple, Jr.
Fitton et al., J. Chem. Soc. (6), 1971, pp. 146 to 149.
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Nakanishi et al., Chem. Abst. vol. 78, abst. 29795j (1973) (abst. of Jap. Pat. 73-42,271).
Lorente et al., Chem. Abst. vol. 83, abst. 178980w (1975).
Temple et al., J. Med. Chem., vol. 22, No. 5, pp. 505 to 510, (1979).

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