Pyropheophorbides and their use in photodynamic therapy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, 5303911, 5303913, 5303915, 5303917, 5303919, 534 14, 540145, A61K 3140, C07D48722

Patent

active

054591597

ABSTRACT:
Pyropheophorbide compounds are injected into a host and accumulate in tumor tissue to a higher degree than surrounding normal tissues. When the pyropheophorbide compounds are exposed to a particular wavelength of light the compounds become cytotoxic and destroy the tumor or diseased tissue without causing irreversible normal tissue damage. The pyropheophorbide compounds have shown improved results as compared to drugs currently used in photodynamic therapy. Further, they absorb light further in the red, optimizing tissue penetration and are retained in the skin for short time periods relative to other drugs used in photodynamic therapy.

REFERENCES:
patent: 4649151 (1987-03-01), Dougherty et al.
patent: 4849207 (1989-07-01), Sakata et al.
patent: 4883790 (1989-11-01), Levy et al.
patent: 4920143 (1990-04-01), Levy et al.
patent: 5002962 (1991-03-01), Pandey et al.
patent: 5093349 (1992-03-01), Pandey et al.
patent: 5198460 (1993-03-01), Pandey et al.
patent: 5314905 (1994-05-01), Pandey et al.
Lipson et al., The Use of a Derivative of Hematoporphyrin in Tumor Detection, 26 J. Natl. Cancer Institute 1-8 (1961).
Dougherty et al., Photoradiation Therapy--Clinical and Drug Advances, 160 Adv. Exp. Med. Biol. 3-13 (1983).
Kessel et al., Chemistry of Hematoporphyrin-derived Photosensitizers, 46 Photochem. and Photobiol. 563-68 (1987).
Scourides et al., Nature of the Tumor-localizing Components of Hematoporphyrin Derivatives, 47 Cancer Research 3439-45 (1987).
Pandey et al., Synthesis and Photosensitizing Activity of a Di-porphyrin Ether, 109 Chem. Abstracts 320, Abstract No. 125066b (1988).
Juergens et al, Chemical Abstracts, vol. 92 (1979) 110984.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pyropheophorbides and their use in photodynamic therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyropheophorbides and their use in photodynamic therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyropheophorbides and their use in photodynamic therapy will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-597636

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.