N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of ox

Details N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of ox N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of ox

1993-11-08

1995-10-17

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514365, 548204, 548236, C07D26332, C07D27730, A61K 31425, A61K 3142

Patent

active

054591546

ABSTRACT:
This invention relates to compounds having 5-lipoxygenase inhibiting properties and inhibition of oxidative modification of low density lipoprotein which have the formula: ##STR1## wherein: R.sup.1 and R.sup.3 are independently hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, or C.sub.1 -C.sub.6 trifluoroalkoxy;

REFERENCES:
Reaven et al., Arteriosclerosis and Thrombosis 12(3), 318-21 (1992).
Steinberg, Amer J. of Cardiology 57, 16H-21H, (1986).
Carew, Schwenke and Steinberg, Proc. Natl. Acad. Sci. 84, 7725-29 (1987).
Nagano et al., Arteriosclerosis 9(4), 453-461 (1989).

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