Multiclass hybrid interferons

Details Multiclass hybrid interferons Multiclass hybrid interferons

1985-07-15

1988-07-19

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 435 68, 435811, A61K 4502, C07K 1300, C07K 1526, C12P 2100

Patent

active

047584289

ABSTRACT:
New multiclass hybrid interferon polypeptides, their corresponding encoding recombinant DNA molecules and transformed hosts which produce the new interferons are described. The amino acid sequences of these hybrids include at least two different subsequences, one of which has substantial homology with a portion of a first class of interferon (e.g., HuIFN-.alpha.) and the other which has substantial homology with a portion of a second class of interferon (e.g., HuIFN-.beta.). Data indicates the interferon activity of .alpha.-.beta. hybrids may be substantially restricted to either cell growth regulatory activity or antiviral activity.

REFERENCES:
patent: 4678751 (1987-07-01), Goeddel
Shepard et al., Nature, vol. 294, pp. 563-565, 1981.

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