Fluorogenic dihydroquinolone and dihydrocoumarin indicators for

Details Fluorogenic dihydroquinolone and dihydrocoumarin indicators for Fluorogenic dihydroquinolone and dihydrocoumarin indicators for

1984-03-27

1985-12-10

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546157, 549399, 435 28, 424 71, C09B 2304

Patent

active

045581304

ABSTRACT:
Fluorogenic indicator compounds responsive to the presence of hydrogen peroxide and methods and test compositions for determining hydrogen peroxide in a test sample. Preferred indicator compounds are 3,4-dihydrocoumarin derivatives and 3,4-dihydro-2-quinolone derivatives, especially those having a dialkylamino group at the 7-position. Such particularly preferred compounds are of the formula: ##STR1## wherein R.sup.1 is hydrogen, cyano, or --COOR.sup.6, --CONHR.sup.6 or --CON(R.sup.6).sub.2 where R.sup.6 is hydrogen, alkyl, alkenyl, or aryl; R.sup.3 and R.sup.4 are lower alkyl; and Y is .dbd.O or .dbd.N--R.sup.5 where R.sup.5 is hydrogen or lower alkyl. The indicator compounds yield highly fluorescent products upon oxidation by hydrogen peroxide in the presence of a peroxidatively active substance and are useful in analytical systems which generate hydrogen peroxide in response to an analyte under determination in a test sample.

REFERENCES:
patent: 4065456 (1977-12-01), Nakagawa et al.
patent: 4105665 (1978-08-01), Harnisch
CA 99:93742a Carbostyrils as Cardiotonic Agents, vol. 99, 1983, Koho.
CA 101:54938j Carbostyril Derivatives; Tanaka et al., vol. 101, 1984.
CA 99:158276y Carbostyril Derivatives; Koho, vol. 99; 1983.

Affiliated with

Also associated with

Rating

Fluorogenic dihydroquinolone and dihydrocoumarin indicators for does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fluorogenic dihydroquinolone and dihydrocoumarin indicators for , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorogenic dihydroquinolone and dihydrocoumarin indicators for will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-59641